IgA Nephropathy- Berger's Disease
IgA Nephropathy, also known as Berger's Disease, is an autoimmune disease. It occurs when the antibody immunoglobin A builds up inside the glomerulus, the part of the nephron that does most of the blood filtration. The glomerulus becomes inflamed due to this immune response, interfering with its function of blood filtration. Eventually, the nephron shuts down, and as immunoglobin A spreads to other nephrons, widespread nephron shut down results in kidney failure.